Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts.Peptide nucleic acids (PNAs) rely on these principles Harnesses Pickup to achieve non-enzymatic gene editing.By forming high-affinity heterotriplex structures within the genome, PNAs have been used to correct multiple human disease-